George and Harold aren't bad kids. They just like to 'liven things up' for everybody. Unfortunately, their thoughtful jokes sometimes get them into a lot of trouble.
When Professor Pippy P. Poopypants becomes their new science teacher... well, George and Harold almost cause the entire planet to be taken over by a maniacal, mad-scientist guy in a giant robot suit!
Who will stop the perilous plot of Professor Poopypants? This looks like a job for Captain Underpants!